Obviously, you must be careful with some drugs given after a checkpoint inhibitor . For example, osimertinib given after a checkpoint inhibitor has a higher incidence of pulmonary toxicity. This is also true with KRAS G12C inhibitors and is more of an issue particularly with sotorasib .
The researchers categorized the cohort by whether they had experienced a clinically meaningful adverse event, defined as one that caused the physician to delay or stop treatment or that required corticosteroids to manage. The investigators also excluded patients with grade 5 toxicity, the most severe class indicating death related to the complication.
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Standard-of-care dermatologic management included general skin prophylaxis per local practice and reactive treatment, such as topical steroids and systemic antibiotics.
Efforts to undo human-induced damage to wildlife by allowing nature to take over again, called rewilding , have taken off in in recent years. In this podcast hosted by James Shooter, a photographer and filmmaker, listeners are taken behind the scenes of various rewilding initiatives across Europe as he travels to visit them during a year-long trip. Monthly episodes tell the stories of people trying to recover nature, for example experts in the Greater Côa Valley in Portugal, who are trying to improve the co-existence of animal species such as rabbits, Iberian wolves and dung beetles. The host’s passion for conservation makes the show both informative and engaging.
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